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The new research shows that HSV relies on a complex of proteins that mediate cargo capture in order to engage microtubules, the host cell鈥檚 intracellular transport network, to reach to the nucleus of a cell
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and replicate.Using imaging techniques, Walsh demonstrated that before HSV moves using dynein, the virus depends on the dynamic nature of microtubules for capture. He observed that these microtubules, which dynamically grow and shrink to sense the intracellular environment, capture virus part
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icles using specialized tracking proteins, EB1 and CLIP-170, at the tips of the microtubules.鈥淭he virus actually sits at the periphery of the cell, and the proteins at
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the tip of the microtubules hook it and grab it on to the microtubule,鈥?Walsh said. 鈥淯p until now, it would be assumed the virus could get on any part of the microtubule as long as it鈥檚 on a motor, but that doesn鈥檛 seem to be the case.鈥漈his finding has 鈥渃hanged the way we think about how the virus gets on the microtubule,鈥?Walsh s RAHIM YAR KHAN:Strict action will be taken a
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gainst those responsible for creating hurdles in vaccinating children during the ongoing polio campaign, said Rahim Yar Khan DCO Zafar Iqbal on Thursday. While directing all polio teams to reach all children under five years of age, he said all resources should
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be utilised to attain 100% targets in the polio drive. The polio
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campaign has been in full swing in Rahim Yar Khan.Published in The Express Tribune, September 30th, 2016.