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Kpwj Discovering a Protein s Role in Gene Expression
Working with mice, scientists at Johns Hopkins publishing in the December issue of Neoplasia have shown that a protein made by a gene called "Twist" may be the proverbial red flag that can accurately distinguish stem cells that drive aggressive, metastatic breast cancer from other breast cancer cells.Building on recent work suggesting tha <a href=https://www.conversede.de>converse schuhe</a> t it is a relatively rare subgroup of stem cells in breast tumors that drives breast cancer, scientists have surmised that this subgroup of cells must have some very distinctive qualities and characteristics.In experiments designed to identify those special qualities, the Hopkins team focused on the gene "Twist" (or TWIST1) 鈥?named for its winding shape 鈥?because of its known role as the produ <a href=https://www.nbbalance.de>new balances 480</a> cer of a so-called transcription factor, or protein that switches on or off other genes. Twist is an oncogene, one of <a href=https://www.nike-dunk.es>nike dunk</a> many genes we are born with that have the potential to turn normal cells into malignant ones."Our experiments show that Twist is a driving force a LAHORE:When Jehan Ara opened her startup incubator Nest I/O last year in Karachi, only one woman applied in the first batch. In the latest one, however, 35% of the applicants were women.For Ara, the ongoing effort to bring more <a href=https://www.nbbalance.it>new balance donna</a> women in the technology sector makes it even more challenging in an environment lacking due support.Pakistani entrepreneurs help farmers get more milk out of their cattlePresident of Pakistan Software Houses Association for IT (P@sha), Ara started her own technology company during the mid 1990s. She comes from a generation of female technologists who helped shape the Pakistani IT industry and brought more women to the job market. Since then many women have made it to the corporate world. But, according to Ara, they still need to forge a system that provides a support structure to allow women to break barriers and get to the top.鈥淲e have women in leadership <a href=https://www.adidassamba.com.de>adidas samba damen</a> <roles> but it is <still> not enough,鈥?she says.As one of the firs <a href=https://www.adidassamba.com.de>adidas samba rose</a> t female leaders in the local IT sector,
  • Charlestereock
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Fujn USAID, health department join hands to fight malnutrition
KARACHI:Muttahida Qaumi Movement (MQM) <a href=https://www.inkwiz.se>ugg boots</a> - Pakistan has termed its victory in the by-polls in five union councils in Karachi a 'fitting' reply to those who believe the party's vote bank in the city has fall <a href=https://www.inkwiz.se>ugg boots tasmania</a> en apart.Addressing a press conference, MPA Faisal Subzwari said his party will also clinch the 2018 general elections in the same manner.Body of missing MQM-Pakistan worker found in KarachiIn Thursday's by-polls, MQM-Pakistan's Danish Ali was elected chairman of District Korangi's UC-20 with 2,925 votes, Muhammad Amir won the s <a href=https://www.campusadidas.it>adidas campus 00's</a> eat of UC-7 chairman with 1,930 votes and Muhammad Mubin Khan secured 2,511 votes to claim UC-35's vice-chairman seat. Aasia Jamshed became the vice-chairperson of District East's UC-4 with 2,195 votes, Muhammad Shahid became the ward councillor in District West's UC-16 and an independent candidate, Allah Rakha, also won a ward councillor seat in District South's UC-1.Subzwari said that in the upcoming general election people would vote for candidates with the k Climate change is causing extinctions at an increasing rate, a newstudyby the University of Arizona researchers shows. They surveyed populations of the Yarrow's spiny lizard in 18 mountain ranges in southeastern Arizona and analyzed the rate of climate-related extinction over time."The magnitude of extinction we found over the past seven years was s <a href=https://www.nbbalance.de>new balance 550</a> imilar to that seen in other studies that spanned almost 70 years," saidJohn J. Wiens, a professor in theDepartment of Ecology a <a href=https://www.asicsgel.de>asic schuh</a> nd Evolutionary Biologyat UArizona, and the senior author of the study.The Yarrow's spiny lizard native to the southwestern U.S. and western Mexico can be spotted in oak and pine forests in 18 of Arizona's Sky Islands mountain ranges. Wiens and h <a href=https://www.adidas-yeezys.es>yeezy slide</a> is group did initial surveys of the Yarrow's spiny lizard in these mountain ranges in 2014 and 2015. In 2021 and 2022, Wiens, along with Kim Holzmann, his former master's student and the lead author of the study, and Ramona Walls, a part-time researcher at UArizona'sBIO5 ins
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Cygs Market watch: Foreigners buy, but index still ends lower
Agilent Technologies Inc. has introduced the first portfolio of internet-based Intelligent Services. Agilent Intelligent Services are designed to enable users to utilize their instruments effectively, resolve problems efficiently, avoid unscheduled shutdowns and make their life science and chemical analysis labs productive. "We鈥檝e designed a highly effective way for our customers to get expert service, sometimes even before they know they have a problem," said May Van, vice president and general manager of Agilent鈥檚 Laboratory Services Solutions business. "Intelligent Services introduce a platform on which all of our services advance to a new level of respons nike dunk iv nike dunk high eness and expertise."Agilent鈥檚 Intelligent Repair service combines standard features of Agilent鈥檚 extended hardware warranty, such as on-site repair, phone support and consumables for repair, as well as new capabil af1 ities, including:- Push for Help: Users can click a Help button on their PC and Agilent experts automatically receive Pop superstar Beyonc茅,聽who is pregnant w uggs hausschuhe ith twins, has pulled out of her headlining spot at the Coachella Music Festival in southern California, event organisers announced on Thursday.Beyonc茅 celebrates black women in intricate album-filmThe event is among the world's premier live music festivals and Beyonc茅's聽performance had been eagerly anticipated.However, "following the advice of her doctors to keep a less rigorous schedule in the com adidas samba nere ing months, Beyonc茅 has made the decision to forgo performing at the 2017 Coachella Valley Music &amp; Ar adidas samba blancas ts Festival," a statement said, adding that "she will be a headliner at the 2018 festival."It was unclear who would take the pop diva's spot at the two-weekend festival in April in Indio, California.Beyonce leads Grammy nominations in crowded fieldThe superstar announced earlier this month that she and husband Jay Z are expecting twins.聽The singer already has a five-year-old daughter, Blue Ivy, with Jay Z. It is unclear when she is due to give birth
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Ncxv BHC bars implementation of unapproved PSDP schemes
Compugen Ltd. has announced that CGEN-25017, a novel peptide antagonist of the Angiopoietin/Tie-2 pathway, has shown positive therapeutic effects in an animal model of retinopathy, a very serious eye condition characterized by over-growth of blood vessels.CGEN-25017, which was initially discovered using Compugen鈥檚 Disease-Associated Conformation (DAC) Blockers discovery platform, had previously demonstrated significant inhibitory activity nike dunks low in two othe dunks r models of angiogenesis, an in vitro multi-cellular assay and the widely recognized chorioallantoic membrane (CAM) model.In the recently completed study utilizing a rodent model of oxygen-induced retinopathy, administration of CGEN-25017 resulted in a dramatic decrease in the extent of pathological neovascularization, outperforming the positive control, soluble Tie-2. These results provide evidence for the potential use of this novel peptide in the treatment of angiogenic ocular diseases, such as diabetic retinopathy, age- adidas yeezy related macular d There comes a time in every band鈥檚 life when they realise they鈥檝e had enough. new balance nere Enough of each other鈥檚 egos, enough of commercial appeasement for financial gains or sometimes just enough of the kind of music they could possibly make as a unit. Aaroh crossed that tipping point more than once for different reasons.First, when the nb 550 ir founding guitarist Nabeel Nihal Chishty left the band, second, when their vocalist Farooq left the country for greener pastures, third and a rather tragic instance was when their exceptionally talented new guitarist, Haider Hashmi, pa adidas samba og ssed away after battling cancer.From fame to oblivion: The music-less story of a Pakistani rock starThe band has gone through so much on a personal level that its real claim to fame, hits like like Na Kaho , Raag Neela and Jalan, seem like a distant memory. However, 2017 will be the year of Aaroh鈥檚 comeback as the band gears up to perform at the upcoming Battle of the Bands as defending champions. 鈥淚 still can鈥檛 get my head around t
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Jjsu Protein Structures Can Provide Keys to Understanding and Preventing Diseases of Catastrophic Proportions
Researchers at Friedrich-Alexander Universit盲t Erlangen-N眉rnberg (FAU), the Paul Scherrer Institute in Switzerland and other institutions in Paris, Hamburg and Basel, have succeeded in setting a new record in X-ray microscopy. With improved diffractive lenses and more precise sample positioning, they were able to achieve spatial resolution in the single-digit nanometer scale. This new dimension in direct imaging could provide significant impulses for research into nanostructures and further advance the development of solar cells and new types of magnetic data storage. The findings have now been published in the renowned journal Optica with the ti converse chucks tle 'Soft X-ray microsc nike dunk panda opy with 7 nm resolution'.Soft X-ray microscopy, which uses low-energy X-rays is used to investigate the properties of materials in the nanoscale. This technology can be used to determine the structure of organic films that play an importan yeezy schuh t role in the development of solar cells and batteries. It also enables chemical pr LAHORE:Speakers at a training session at Lahore College for Women University (LCWU) said on Thursday research in social and biological sciences was vital for the country鈥檚 growth.They were speaking at a nb five-day In-service Short Term Training for University Faculty at the LWCU. The Directorate of Faculty Development and Internationalisation (DFDI) and the Punjab Higher Education Commission (PHEC) had arranged the training. It consisted of 10 sessions on andragogical skills nb 550 , three sessions on micro teaching and four sessions on communication skills. The objective of the workshop was to equip faculty members with advanced teachin stanley store g methodologies, sound communication skills and groom their personality.聽 The speakers said teaching methodologies had changed over the years. They called for using technology, including various multimedia tools, for training teachers. PHEC resource persons for the training included Nusra Inayat, Bashir Gondal and Moafia Nader. They conducted sessions on andragog
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Canz Sindh govt announces Eid holidays
Tap on the metaphorical fuel tanks of any of the political parties operating in Pakistan and there will be a hollow ringin adidas samba og g noise. A noise indicative of 鈥榚mpty鈥?beyond a whiff of whatever might have been the go-juice when the party was founded. To be sure there is a superstructure surrounding the tank that looks like a political vehicle, and it might be reasonable to expect that there would be, swirling around in the tank, essence of the elements that made the party whatever it was at its inception 鈥?leadership and moral authority. But nothing. And herein lies the answer to the question so often asked 鈥?where is the solution to the terror problem and why has it not b adidas samba og een cracked thus far?In large part it is down to an absence of moral authority nb balance and a failure of leadership. There is no shortage of bombast and rhetoric and soundbites by the basketful. Press releases abound as do vox-pops and occasional guest appearances in whatever elected body comes to hand. But there is no sense of unit Study Also Finds &lsquo;Brain Gender&rsquo; May Be More Flexible Than Previously RealizedDuring prenatal development, the brains of most animals, including humans, develop specifically male or female characteristics. In most species, some portions of male and female brains are a different size, and often have a different number of neurons and synapses. However, scientists have known yeezy 700 little about how this differentiation occurs. Now, a new study by researchers at the University of Maryland School of Medicine (UM SOM) has illuminated details about this process.Margaret McCarthy, PhD, professor and chairman of the Department of Pharmacology, studied brain development in newborn rats. She found that giving estradiol, a testosterone derivative, triggers a mechanism by which certa yeezy in genes in the brain are &quot;unsilenced,&quot; a nike dunk high llowing them to initiate the process of masculinization. This process involves a group of enzymes known as DNA methyltransferases, or Dnmts, which modify DNA to rep

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