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Since 1993, when the gene that causes Huntington's disease (HD) was identified, there has been intense focus on understanding how this genetic mutation causes the disease's severe progressive neural deterioration. In a new study published in the Journal of Huntington's Disease, investigators have discovered that the HD mutation may alter the interactions of Huntingtin, the large p <a href=https://www.adidas-yeezys.com.mx>tenis yeezys</a> rotein produced by the HD <a href=https://www.yeezy.com.mx>yeezy 500</a> gene, with Rac1, a protein that directs changes in cell shape. In HD, this interaction may result in abnormalities in the pathway controlling neural cell shape and dendritic growth, which can affect how well nerve cells communicate with one another.鈥淲e are excited about this finding because it describes a functional change that occurs very early in HD models, including in human neurons, and might underlie the earliest changes experienced by HD patients. Rac1 is currently a <a href=https://www.nike-dunks.de>nike dunk sb </a> major target of investigation in the cancer field and in Crohn鈥檚 disease, so compounds that can modify its functi ISLAMABAD:State Grid of China will help build a 4,000 MW power transmission line in Pakistan in a project valued at $1.5 billion, a statement issued by the PM House said on Friday, the latest in a series of Chinese investments in the country.The high-capacity transmis <a href=https://www.campusadidas.fr>adidas campus blanche</a> sion line will be the first of its kind in Pakistan and will link Matiari town, near a new power station, to Lahore city, a key link in transmission infrastructure.An agreement on the project was signed on Thursday in Beijing between Mohammad Younus Dagha, secretary of water and p <a href=https://www.adidassamba.com.de>adidas samba sale</a> ower, and Shu Yinbiao, chairman of State Grid Corporation of China, the <a href=https://www.adidascampus.com.de>adidas campus gr眉n</a> statement added.Addressing electricity crisis: 436 power projects worth Rs372m initiated in DG KhanConstruction will begin in January, and should take about 20 months, said a spokesperson for the prime minister's office.The project is the latest in a series of big Chinese investments, most of which fall under a planned $55 billion worth of projects for a China-Pakistan Economi
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Stemgent, Inc. and iPS Academia Japan, Inc. have announced a worldwide non-exclusive licensing agreement for AJ鈥檚 induced pluripotent stem cell (iPSC) patent portfolio.The portfolio arises from work by Professor Shinya Yamanaka, MD, PhD, Center for iPS Cell Research and Application (CiRA) at the University of Kyoto, Japan.With the rights granted through this agreement, Stemgent can continue to lead the field in develo <a href=https://www.yeezyy.at>yeezys 350</a> ping the most innovative iPS technologies and services for the academic community and also be able to extend these rights, through a sub-license agreement, to commercial entities for drug screening applications.This wil <a href=https://www.nike-dunk.it>nike dunk high</a> l enable biotech and pharmaceutical researchers to take full advantage of the premier non-integrating reprogramming technique, Stemgent mRNA Reprogramming System.The Stemgent mRNA Technology is currently the fastest, safest and most efficient approach to reprogramming somatic cells <a href=https://www.adidas-yeezy.it>yeezy</a> .With this framework, both parties aim to simplify access to iPS cell technolo SARGODHA:A boy was crushed to death by a train in the jurisdiction of Sajid Shaheed police station on Tuesday.Eight students among nine dead as train crashes into rickshaw in LodhranPolice said that 17-year-old Sahil Omer, a resident of Police Lines, was travelling in Millat Express when he lost his balance and slipped from the footbo <a href=https://www.nbbalance.es>new balance 480</a> ard. As a result, he was crushed under the wheels of the train near Trust Plaza Building. The police shifted the body to the hospital for legal formalities.Earlier in January this year, a聽train in Lodhran聽crashed into a motorised rickshaw, killing eight聽children and the rickshaw driver who were on their way to school, railway聽authorities said.21 dead as trains collide near Karachi' <a href=https://www.nbbalance.es>nb mujer</a> s Landhi Railway StationThe childre <a href=https://www.nbbalance.it>nb 530</a> n killed in the crash, in the south of Punjab province, were aged six to 10, District Police Officer Lodhran Asad Sarfraz said. He added聽that the gate at the crossing was open at the time of the accident, meaning traffic on the road could cross
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Momina Mustehsan continues to be an all-time favourite and this recent post is just another proof of that.Momina posted a video of Australian cricketer Shane Watson congratulating her for becoming a part of the Pakistan Super League (PSL) Islamabad United franchise.Momina captioned聽the video saying, "Hahaha THANKS for the welcome wish."Mom <a href=https://www.stanley-cup.com.de>stanleycup</a> ina Mustehsan gets engaged in private ceremonyShane also interspersed his message with afreen afreen, evoking memories of Momina's celebrated Coke Studio appearance.
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A new study published by researchers from Baylor College of Medicine and UT Health鈥檚 McGovern Medical School in the Proceedings of the National Academy of Sciences reveals an unprecedented close-up view of cilia linked to blindness. Cilia are short hair-like structures found on the surface of certain cells. They are particularly important in visi <a href=https://www.adidas-yeezy.it>Scarpe Yeezy</a> on because they work as light sensors and defects in their structure can lead to retinal degeneration and loss of vision. Studying cilia structural alterations has previously been limited to the resolution capacity of traditional imaging technologies.In the current study, re <a href=https://www.adidas-yeezy.de>yeezy schuh</a> searchers reported the development and application of <a href=https://www.adidas-yeezy.it>yeezy slides</a> new imaging methods that provided a higher resolution view of the internal structure of normal and diseased retinal cilia. They discovered previously unknown compartments within the cilia and the location of some of the proteins involved in retinal disease. Their findings contribute to a better understanding of the struct ISLAMABAD:Police have found no evidence that the man who had restrained MNA Sheikh Rahid Ahmed outside the Parliament on Thursday also threatened him. Malik Noor Awan had been arrested by the police after he stopped Ahmed at the parliament entrance and demanded Rs2.2 million which he claimed Rashid owed him for many years.Awan, who claimed to be president of the PML-N in Japan, said that Rashid owed him the amount fr <a href=https://www.adidas-samba-adidas.fr>samba og adidas</a> om an auto deal in <a href=https://www.stanley-cup.us>stanleycup</a> Japan many years ago. Secretariat police had booked Awan for allegedly threatening and restraining Rashid on the latter鈥檚 complaint.PML-N worker held for 'intimidating' Sheikh Rashid outside聽ParliamentHe was engaged in an argument with Rashid as soon as he came out of <a href=https://www.stanley-cup.us>stanley-cup</a> the National Assembly and demanded payment of the amount. A number of people including journalists gathered at the scene and recorded the incident on their mobile phones and cameras.As the confrontation intensified, Rashid was helped by a man at the scene to walk back inside the Parliament g

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