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Moderna, Inc., (Nasdaq: MRNA) a clinical stage biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, has announced the first patient has been dosed in the Phase 1/2 study evaluating the safety and tolerability of mRNA-3705, its investigational mRNA therapeutic for methylmalonic acidemia (MMA), administered via intravenous infusion in patients with isolated MMA due to MUT deficiency.鈥淲e would like to thank Dr. Santra and the whole team in Birmingham for their efforts and collaboration to achieve this milestone moment of dosing the first MMA patient with our mRNA therapeutic,鈥?said Ruchira Glaser, M.D., Sr. <a href=https://www.nbbalance.de>new balance 9060</a> Vice President and Therapeutic Area Head, Rare Disease, Autoimmune &amp; Cardiovascular. 鈥淭his is another step forward in Moderna鈥檚 mission to deliver on the promise of mRNA science to create a <a href=https://www.adidas-yeezys.fr>adidas yeezy</a> new generation of transformative medicines for patients.鈥濃€淲e are delighted to have been able to treat the first <a href=https://www.nike-dunk.es>dunk cacao</a> patient in the world with this new medicine here in Bi KARACHI:Pakistan U21 hockey team defeated Maartensdijkse Mixed Hockey Club (MMHC) Voordaan of Netherlands 6-3 in the opening match of their European tour yesterday.Interestingly, six different players got on the scoring sheet for the visitors. Three goals were scored in open play with as many coming through penalty corner conv <a href=https://www.nbbalance.fr>newbalance 9060</a> ersions.Sohail Riaz, Shan Irshad and Dilber Hussain had field goals to their names, while Mubashar Ali, Abubakr and Hasan Anwar found the target through penalty corners.9-a-Side hockey: Arshad steers team to victoryTeam captain Dilber H <a href=https://www.adidassamba.com.de>adidas samba herren</a> ussain told The Express Tribune that the opponents were a junior team of the club who had been training throughout the year. 鈥淭hey had good skills; howev <a href=https://www.adidascampus.com.de>adidas campus gr眉n</a> er, we had more international experience and we followed instructions given by our coaches,鈥?he said.鈥淥ur team was strong because we covered for one another and assisted goals for each other. Our game play and stamina improved after the 9-a-side tournament in Karachi recently,鈥?said
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Research scientists have developed a novel method to re-create brain and <a href=https://www.yeezyy.at>yeezy slide</a> intestinal stem cells from patients who died decades ago, using DNA from stored blood samples to study the potential causes of debilitating illnesses such as inflammatory bowel disease.The lab research, published in the journal STEM CELLS Translational Medicine, coul <a href=https://www.nikeairforces.de>air force</a> d yield new therapies for people who suffer from aggressive motor-neuron and gut-related <a href=https://www.nbbalance.de>new balance sneaker</a> conditions that proved fatal to the deceased patients who long-ago volunteered their blood samples."The potential implications of this research are vast," said Dhruv Sareen, PhD, the study's lead author, and assistant professor and director of the David and Janet Polak Foundation Stem Cell Core Laboratory in the Board of Governors Regenerative Medicine Institute.By using a deceased patient's stored blood samples, Sareen and his colleagues found that they can develop stem cells known as iPSCs in a petri dish 鈥?essentially reanimating diseased cells from patients lon LAHORE:The government of Punjab has decided to enforce property tax on all vacant plots across the province, officials say.The Punjab Excise and Taxation (E&amp;T) Department has already completed surveys in major cities including Lahore, Faisalabad, Multan and Gujranwala and identified <a href=https://www.campusadidas.it>adidas campus verdi</a> about 250,000 vacant plots that will come under the property tax net.FBR notifies property valuation rates for 16 citiesEstimates suggest the government will collect a revenue of at least Rs150 million from owners of these plots in the current fiscal year.The tax will be imposed on all residential and commercial plots lying vacant for the past two years. Property owners will hav <a href=https://www.stanley-cup.us>stanley products</a> e to pay annually Rs1,500 on five <a href=https://www.campusadidas.it>adidas campus nere</a> -marla (125-square-yard) plots, Rs3,100 on 10-marla (250-square-yard) plots and Rs7,000 on one-kanal (500-square-yard) plots.Plots located in all government and private housing societies and areas falling within the jurisdiction of the E&amp;T Department, except for cantonment areas, will come und
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Distributed Bio and Twist Bioscience have announced a collaboration to offer therapeutic antibody design and optimization services, as well as an exclusive G-protein coupled receptor (GPCR) targeting library, for Twist Bioscience customers. The custom software, to be developed by Distributed Bio exclusively for Twist Bioscience, will enable pharmaceutical and biotechnology companies to easily use Twist Bioscience鈥檚 high-throughput long oligo synthesis technology to revolutionize how they design, engineer and optimize their antibody leads to ident <a href=https://www.adidas-yeezys.fr>yeezy 500</a> ify high quality, <a href=https://www.adidas-yeezy.it>yeezy boost</a> fully-human antibody therapeutics while simultaneously receiving synthetic DNA to complete early drug discovery.Addi <a href=https://www.nikeairforces.de>nike air force 1</a> tionally, the proprietary GPCR targeting antibody library will be available for customers to screen, in order to identify novel therapeutics against this valuable class of targets. 鈥淒istributed Bio is singularly qualified, through their depth and breadth of experience designing antibodies based on the natural hum MANCHESTER:Kagiso Rabada took th <a href=https://www.campusadidas.it>adidas campus bianche</a> e prize wicket of Ben Stokes as South Africa held England to 260 for six on Friday's first day of the fourth Test at Old Trafford.Al <a href=https://www.adidassamba.com.de>adidas samba adidas</a> l-rounder Stokes, fresh from a hundred in England's 239-run victory in the third Test at The Oval, was leading host鈥檚 revival with the bat.But fast-bowler Rabada struck with the new ball in the penultimate over of the day when a full-length delivery, which surprised Stokes, smashed into the base of the stumps and bowled the left-handed batsman for 58.Du Plessis return gives South Africa hopeRabada, banned from the second Test for swearing at Stokes in the series opener, yelled in joy.He finished the day with figures of two for 52 in 18 overs, but the worth of South Africa's efforts as they seek a win that would see them end the series all square at 2-2 will only become fully apparent <a href=https://www.campusadidas.it>adidas campus</a> when they bat.Jonny Bairstow, who might have fallen for four, was 33 not-out and nightwatchman Toby Roland-Jones unbeaten on nought at the clos
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ISLAMABAD:The Ministry of Ports and Shipping is all set to start a ferry service between Karachi and Gwadar from March in an effort to facilitate both cargo and passenger traffic including trips for tourists.The first-ever ferry service from the country鈥檚 industrial hub to the newly devel <a href=https://www.nbbalance.es>new balance 480</a> oped port city will be inaugurated by Prime Minister Nawaz Sharif in the mid <a href=https://www.valela.at>ugg fellboots</a> dle of next month.Pakistan Navy increases surveillance at Gwadar portDuring his visit to Gwadar in January, the premier had issued instructions for making arrangements in this regard.He felt the need of the service in order to facilitate general commuters and tourists as well as security officials and civilians who were working in Gwadar and asked the ports and shipping authorities to start the facility immediately.In addition to the cargo, the vessel would have the capacity to accommodate more than 400 passengers.鈥淭he ferry will carry touri <a href=https://www.campusadidas.it>adidas campus rosa</a> sts, officials and general passengers between Karachi and Gwadar and will be faster than At holida <a href=https://www.adidas-yeezy.it>yeezy slides</a> y buffets and potlucks, people make quick calculations about which dishes to try and how much to take of each. Johns Hopkins University neuroscientists have found a brain region that appears to be strongly connected to such food preference decisions.Researchers, working with rats, found robust neural activity related to food choice in a previously overlooked part of the brain. The finding suggests this brain area could be key to developing therapies and treatments to encourage healthy eating. The findings are set for publication in the journal Nature Communications."We found a region in the brain that refle <a href=https://www.adidas-yeezys.es>yeezy boost</a> cts our perception of food in a strikingly dominant way," said lead author David Ottenheimer, a Johns Hopkins University graduate student studying neuroscience. "The <a href=https://www.nike-dunk.es>dunk nike high</a> level of brain activity we saw exceeded our expectations by far."The research team wanted to know how the brain determines what and how much to eat when someone has several good food options. It's a situation pe
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Mact Over 33,000 appear for K-P medical colleges entrance test
Your brain handles a perceived threat differently depending on how close it is to you <a href=https://www.adidas-yeezys.com.mx>chanclas yeezy</a> . If it鈥檚 far away, you engage more problem-solving areas of the brain. But up close, your animal instincts jump into action and there isn鈥檛 as much reasoning, like when the guy at the haunted house jumps up right next to you.And that, according to a new study using virtual reality to make threats appear near or far, is probably what makes it harder to extinguish the fear of a close-up threat and more likely that you鈥檒l have some long-term stress from the <a href=https://www.nike-dunk.es>dunk low mujer</a> experience.It has been sho <a href=https://www.adidas-yeezy.de>yeezys 700</a> wn that traumatic events that touch the body, like rape and other physical assaults, are more strongly associated with post-traumatic stress disorder than are traumas viewed at some distance.Now, thanks to a clever adaption that put research subjects into a 3D virtual reality environment while their brains were being scanned by an MRI machine, researchers have seen just how the circuitry of those brain responses differ.鈥淐lini ISLAMABA <a href=https://www.stanley-cup.com.de>stanley cup</a> D:The chairman of Jammu and Kashmir Liberation Front, Yasin Malik while terming the the boycott in Indian-held Kashmir a referendum against illegal-occupation, said the five per cent theory of Mehbooba Mufti has come true with a revelation that even five per cent of Kashmiris are not with India, APP reported.OIC rallies behind Pakistan over ongoing unrest in SrinagarJKLF chairman extended condolences to the bereaved families of the demonstrators who <a href=https://www.adidascampus.com.de>adidas campus herren</a> were killed yesterday in a statement issued in Srinagar, according to the Kashmir Media Service.Malik said the "Indian rulers, their stooges and occupational forces cannot force Kashmiris into submission" through "killing sprees, maiming and other oppressive measure".鈥淔rom last seven months <a href=https://www.campusadidas.fr>adidas campus 80s</a> hundreds of our kith and kin are being killed, thousands and being maimed and blinded but the resilience of Kashmiris has not been shaken and our resistance remains steadfast as ever," the statement added.Malik said that "frustrated by the exempl
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GENEVA:The Syrian opposition said on Friday armed groups fightin <a href=https://www.campusadidas.it>adidas campus rosa</a> g President Bashar al-Assad wou <a href=https://www.adidas-samba-adidas.es>adidas samba hombre</a> ld respect a two-week week truce beginning at midnight, but said the government and its allies must not launch attacks on the pretext of fighting terrorism." <a href=https://www.stanley-cup.com.de>stanley shop</a> The High Negotiations Committee confirms the agreement of the Free Syrian Army factions and the armed opposition to a temporary truce from midnight Saturday," an HNC statement said.The HNC said the government and its allies must not use the "proposed text to continue the hostile operations against the opposition factions under the excuse of fighting terrorism". One injection of a candidate monoclonal antibody (mAb) known as L9LS was found to be safe and highly protective in U.S. adults exposed to the malaria parasite, according to res <a href=https://www.adidas-yeezy.it>ciabatte yeezy</a> ults from a National Institutes of HealthPhase 1 clinical trialpublished inThe New England Journal of Medicine. Additional clinical trials evaluating if L9LS can prevent malaria over six to 12 months against seasonal and perennial <a href=https://www.nike-dunks.de>dunk nike low</a> transm <a href=https://www.nbbalance.de>nb</a> ission are underway in infants and children inMaliandKenya, where malaria is endemic. The trial was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH.鈥淭hese early clinical trial results demonstrating that a monoclonal antibody administered subcutaneously can protect people from malaria are highly encouraging,鈥?said NIAID Director Anthony S. Fauci, M.D. 鈥淎 one-time intervention that protects against malaria for six months to a year could significantly reduce morbidity and mortality among children in malaria-endemic regions and offer an effe

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