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Compugen Ltd. has announced that CGEN-25017, a novel peptide antagonist of the Angiopoietin/Tie-2 pathway, has shown positive therapeutic effects in an animal model of retinopathy, a very serious eye condition characterized by over-growth of blood vessels.CGEN-25017, which was initially discovered using Compugen鈥檚 Disease-Associated Conformation (DAC) Blockers discovery platform, had previously demonstrated significant inhibitory activity
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r models of angiogenesis, an in vitro multi-cellular assay and the widely recognized chorioallantoic membrane (CAM) model.In the recently completed study utilizing a rodent model of oxygen-induced retinopathy, administration of CGEN-25017 resulted in a dramatic decrease in the extent of pathological neovascularization, outperforming the positive control, soluble Tie-2. These results provide evidence for the potential use of this novel peptide in the treatment of angiogenic ocular diseases, such as diabetic retinopathy, age-
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ssed away after battling cancer.From fame to oblivion: The music-less story of a Pakistani rock starThe band has gone through so much on a personal level that its real claim to fame, hits like like Na Kaho , Raag Neela and Jalan, seem like a distant memory. However, 2017 will be the year of Aaroh鈥檚 comeback as the band gears up to perform at the upcoming Battle of the Bands as defending champions. 鈥淚 still can鈥檛 get my head around t