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Combining a pair of experimental drugs may help treat malignant peripheral
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nerve sheath tumors with fewer harmful side effects, according to preliminary animal studies led by investigatorsat theJohns Hopkins Kimmel Cancer CenterandJohns Hopkins Drug Discovery.The study, published Dec. 1 inthe journalMolecular Cancer Therapeutics, shows that combining an experimental drug that blocks the metabolism of the amino acid glutamine with a second experimental drug that blocks recycling of purines (building blocks of the gene
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tic material DNA and RNA that tumors need to proliferate) reduced the size of peripheral nerve sheath tumors in mice and increased their rates of survival. The combination was less toxic than previously tested drug combinations.鈥淯sing these broadly active metaboli
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c inhibitors can help us better understand how these tumors are using nutrients to build what they need to make more tumor cells,鈥?says lead study authorKathryn Lemberg, M.D., Ph.D.,an assistant professor of oncolo Counting of votes for 41 direct
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ly-contested seats of the Azad
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Jammu Kashmir Legislative Assembly has begun as voting concluded at 5pm on Thursday.AJK Chief Election Commissioner Justice Ghulam Mustafa
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Mughal visited polling stations in Muzaffarabad, reported聽Radio Pakistan.Mughal said no complaint of mishap or violence was reported during the polling from anywhere in the valley.He thanked the federal government and Pakistan Army for ensuring the transparent conduct of polls. An elderly Kashmiri casts his ballot at a polling station in the general elections in Muzaffarabad on July 21, 2016. PHOTO: AFP